A case study on ongoing cerebellar impairment after acute lithium overdose - Takeaways - MDSpire

A case study on ongoing cerebellar impairment after acute lithium overdose

  • By

  • Jiabei Nie

  • Qing Gao

  • Yiming Li

  • Xiaomeng Xu

  • Yuyan Tan

  • March 9, 2026

  • 0 min

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  • 1

    Lithium overdose can lead to severe neurological symptoms, including persistent cerebellar dysfunction, even after lithium levels normalize.

  • 2

    The patient in this case study experienced acute lithium toxicity with symptoms like seizures, altered mental status, and muscle rigidity.

  • 3

    Despite treatment, the patient developed ongoing symptoms such as dysarthria, dizziness, and unsteady gait, indicating long-term cerebellar impairment.

  • 4

    Rehabilitation therapy focused on improving balance and coordination, but the patient's progress plateaued, leaving residual symptoms.

  • 5

    The case highlights the need for awareness of potential long-term effects of lithium toxicity, particularly cerebellar ataxia.

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