Assessing the Impact of Plasma Cell-Free DNA Methylation Monitoring on Predicting Pathological Outcomes in Resectable Stage IIB-IIIB Non-Small Cell Lung Cancer: Insights from a Prospective Phase II Study - Takeaways - MDSpire

Assessing the Impact of Plasma Cell-Free DNA Methylation Monitoring on Predicting Pathological Outcomes in Resectable Stage IIB-IIIB Non-Small Cell Lung Cancer: Insights from a Prospective Phase II Study

  • By

  • Bing Liu

  • Ye Tao

  • Minglei Zhuo

  • Li-Di Xu

  • Xueyan Cheng

  • Wei Tao

  • Zhangdong Xie

  • Chao Lv

  • Yuzhao Wang

  • Shaolei Li

  • Shanyuan Zhang

  • Miao Huang

  • Yaqi Wang

  • Xiang Li

  • Yuge Zhu

  • Xinrui Cui

  • Xuantong Zhou

  • Bateer Han

  • Enli Zhang

  • Yu S. Huang

  • Weizhi Chen

  • Jia Wang

  • Shi Yan

  • Nan Wu

  • November 5, 2025

  • 0 min

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  • 1

    The study investigates the efficacy of neoadjuvant toripalimab plus chemotherapy in resectable stage IIB-IIIB non-small cell lung cancer.

  • 2

    Circulating cell-free DNA methylation features may serve as predictive biomarkers for treatment response in neoadjuvant chemoimmunotherapy.

  • 3

    The trial enrolled 100 patients with specific inclusion criteria, including clinical stage IIB to IIIB NSCLC and adequate organ function.

  • 4

    Methylation profiling and chromosomal aneuploidy scores were analyzed to assess their association with pathological response.

  • 5

    An integrated model combining cfDNA features and immune parameters was developed to enhance prediction of pathological outcomes.

Original Source(s)

Assessing the Impact of Plasma Cell-Free DNA Methylation Monitoring on Predicting Pathological Outcomes in Resectable Stage IIB-IIIB Non-Small Cell Lung Cancer: Insights from a Prospective Phase II Study

  • by Bing Liu, Ye Tao, Minglei Zhuo, Li-Di Xu, Xueyan Cheng, Wei Tao, Zhangdong Xie, Chao Lv, Yuzhao Wang, Shaolei Li, Shanyuan Zhang, Miao Huang, Yaqi Wang, Xiang Li, Yuge Zhu, Xinrui Cui, Xuantong Zhou, Bateer Han, Enli Zhang, Yu S. Huang, Weizhi Chen, Jia Wang, Shi Yan, Nan Wu

  • November 5, 2025

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