Effects of meropenem plus ulinastatin on inflammatory response and complications in patients with severe septic shock - Takeaways - MDSpire

Impact of Combining Meropenem and Ulinastatin on Inflammatory Responses and Complications in Severe Septic Shock Patients

  • By

  • Dan Wu

  • Wei Ni

  • Xinying Zhang

  • Xiaodong Liu

  • July 21, 2026

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  • 1

    The study evaluated the effects of ulinastatin combined with meropenem on patients with severe septic shock.

  • 2

    The observation group receiving ulinastatin showed a higher overall response rate of 90.6% compared to 73.6% in the control group.

  • 3

    Post-treatment, the observation group had significantly lower levels of inflammatory markers such as CRP and IL-6.

  • 4

    Patients in the observation group experienced improved hemodynamic parameters and shorter ICU stays and mechanical ventilation durations.

  • 5

    The complication rate was lower in the observation group at 9.4%, compared to 24.5% in the control group.

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