BAG3+ CAF-T cell neighborhood predicts resistance to neoadjuvant chemoimmunotherapy in NSCLC - Takeaways - MDSpire

BAG3+ CAF-T cell neighborhood predicts resistance to neoadjuvant chemoimmunotherapy in NSCLC

  • By

  • Jing Sun

  • Zhengqi Cao

  • Yueping Jin

  • Anni Wang

  • Li Lu

  • Lixuan Chen

  • Wenhui Shi

  • Peiyi Xu

  • Yuxin Ouyang

  • Junjie Tang

  • Zhouwenli Meng

  • Ziming Li

  • July 7, 2026

  • 0 min

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  • 1

    Over 40% of non-small cell lung cancer (NSCLC) patients do not achieve major pathological response (MPR) after neoadjuvant chemoimmunotherapy (NCIT).

  • 2

    The study identified BAG3+IFITM2+ cancer-associated fibroblasts (CAFs) and BAG3+CD8+ T cells as significant markers associated with non-response to NCIT.

  • 3

    The BAG3+ CAF-T Cell Neighborhood was significantly more abundant in non-MPR patients compared to MPR patients, indicating its predictive value.

  • 4

    AUC values for BAG3+IFITM2+ CAFs, BAG3+CD8+ T cells, and the BAG3+ CAF-T Cell Neighborhood were 0.84, 0.72, and 0.87, respectively.

  • 5

    The study suggests that the BAG3+ CAF-T Cell Neighborhood may serve as a biomarker for predicting non-response to NCIT in NSCLC.

Original Source(s)

BAG3+ CAF-T cell neighborhood predicts resistance to neoadjuvant chemoimmunotherapy in NSCLC

  • by Jing Sun, Zhengqi Cao, Yueping Jin, Anni Wang, Li Lu, Lixuan Chen, Wenhui Shi, Peiyi Xu, Yuxin Ouyang, Junjie Tang, Zhouwenli Meng, Ziming Li

  • July 7, 2026

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