Comparison of infectious complications with BCMA-directed therapies in multiple myeloma - Takeaways - MDSpire

Comparison of infectious complications with BCMA-directed therapies in multiple myeloma

  • By

  • Karthik Nath

  • Tala Shekarkhand

  • David Nemirovsky

  • Andriy Derkach

  • Bruno Almeida Costa

  • Noriko Nishimura

  • Tasmin Farzana

  • Colin Rueda

  • David J. Chung

  • Heather J. Landau

  • Oscar B. Lahoud

  • Michael Scordo

  • Gunjan L. Shah

  • Hani Hassoun

  • Kylee Maclachlan

  • Neha Korde

  • Urvi A. Shah

  • Carlyn Rose Tan

  • Malin Hultcrantz

  • Sergio A. Giralt

  • Saad Z. Usmani

  • Zainab Shahid

  • Sham Mailankody

  • Alexander M. Lesokhin

  • May 31, 2024

  • 0 min

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  • 1

    BCMA-directed therapies have evolved significantly for treating relapsed/refractory multiple myeloma, including CAR-T and BsAb therapies.

  • 2

    Infectious complications associated with BCMA-directed T-cell redirecting therapies are increasingly reported, highlighting the need for awareness.

  • 3

    This study analyzed infectious complications in 256 patients receiving BCMA-targeting CAR-T, BsAb, or ADC therapies at Memorial Sloan Kettering.

  • 4

    The primary endpoint was the incidence of severe infections, with secondary endpoints assessing infection rates, organisms, and risk factors.

  • 5

    Statistical analyses included Cox proportional-hazard models and Poisson regression to evaluate infection risks and treatment associations.

Original Source(s)

Comparison of infectious complications with BCMA-directed therapies in multiple myeloma

  • by Karthik Nath, Tala Shekarkhand, David Nemirovsky, Andriy Derkach, Bruno Almeida Costa, Noriko Nishimura, Tasmin Farzana, Colin Rueda, David J. Chung, Heather J. Landau, Oscar B. Lahoud, Michael Scordo, Gunjan L. Shah, Hani Hassoun, Kylee Maclachlan, Neha Korde, Urvi A. Shah, Carlyn Rose Tan, Malin Hultcrantz, Sergio A. Giralt, Saad Z. Usmani, Zainab Shahid, Sham Mailankody, Alexander M. Lesokhin

  • May 31, 2024

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