Prognostic significance of atrial functional mitral regurgitation in patients with HFpEF and end-stage renal disease

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Atrial functional mitral regurgitation (AFMR) significantly increases all-cause mortality in patients with heart failure with preserved ejection fraction (HFpEF) and end-stage renal disease (ESRD).
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Multivariate analysis identified AFMR as an independent predictor of all-cause mortality, with even mild AFMR associated with elevated risk.
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Moderate to severe AFMR correlates with a higher incidence of cardiac function decline compared to both non-AFMR and mild AFMR cohorts.
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Plasma atrial natriuretic peptide (ANP) concentrations are significantly higher in AFMR patients and may serve as a potential biomarker for identifying AFMR.
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The study underscores the need for prompt recognition and treatment of AFMR in patients with HFpEF and ESRD undergoing hemodialysis.

Frontiers In Cardiovascular Medicine

by Yuanyuan Wang, Bingya Lv, Yangyang Chen, Zhe Wang, Botao Hu, Yu Xiao, Haodong Du, Xiaoyi Zhang, Shuai Shao, Ya Suo, Qiankun Bao
May 15, 2026

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