Lactylation: a metabolic–epigenetic driver in atherosclerosis pathogenesis and therapeutic targeting - Takeaways - MDSpire

Lactylation: a metabolic–epigenetic driver in atherosclerosis pathogenesis and therapeutic targeting

  • By

  • Wenbo Lv

  • Linxi Xie

  • Jintao Tao

  • Qingqi Xu

  • Wenfeng Hu

  • Hao Xie

  • Pin Lu

  • Ying Xu

  • Liang Huang

  • June 26, 2026

  • 0 min

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  • 1

    Lactylation is a post-translational modification that adds lactate-derived lactyl groups to lysine residues on proteins.

  • 2

    Lactylation plays a crucial role in atherosclerosis by regulating inflammation, endothelial-to-mesenchymal transition, and metabolic dysregulation.

  • 3

    Histone acetyltransferase p300 may function as a lactyltransferase, mediating lactylation of histones H3 and H4.

  • 4

    Class I histone deacetylases and sirtuins exhibit delactylase activity, suggesting their role in regulating lactylation.

  • 5

    Understanding lactylation's molecular mechanisms is essential for developing interventions to slow atherosclerosis progression.

Original Source(s)

Lactylation: a metabolic–epigenetic driver in atherosclerosis pathogenesis and therapeutic targeting

  • by Wenbo Lv, Linxi Xie, Jintao Tao, Qingqi Xu, Wenfeng Hu, Hao Xie, Pin Lu, Ying Xu, Liang Huang

  • June 26, 2026

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