Exploration of the longitudinal clinical course and potential prognostic factors in Parkinson’s disease: 2.5-year observational study in Japan - Takeaways - MDSpire

Exploration of the longitudinal clinical course and potential prognostic factors in Parkinson’s disease: 2.5-year observational study in Japan

  • By

  • Kei-ichi Ishikawa

  • Yushin Tominaga

  • Yu Kigoshi-Tansho

  • Kentaro Ohta

  • Ayami Suzuki

  • Yuanzhe Li

  • Wado Akamatsu

  • Shinji Saiki

  • Nobutaka Hattori

  • May 26, 2026

  • 0 min

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  • 1

    The study analyzed 348 patients with Parkinson's disease (PD) at Juntendo University Hospital in Japan over 2.5 years.

  • 2

    Most patients had mild to moderate PD, with a mean age of 66.4 years and a mean disease duration of 6.22 years.

  • 3

    The mean UPDRS III score improved by 3.3 points at the 6-month visit and remained stable for up to 2.5 years.

  • 4

    Baseline motor severity, time from PD onset to referral, and orthostatic hypotension were linked to clinically relevant worsening.

  • 5

    Timely referral to specialized care and assessment of autonomic symptoms may help identify patients at higher risk of worsening.

Original Source(s)

Exploration of the longitudinal clinical course and potential prognostic factors in Parkinson’s disease: 2.5-year observational study in Japan

  • by Kei-ichi Ishikawa, Yushin Tominaga, Yu Kigoshi-Tansho, Kentaro Ohta, Ayami Suzuki, Yuanzhe Li, Wado Akamatsu, Shinji Saiki, Nobutaka Hattori

  • May 26, 2026

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