Safety outcomes of mucomuscular closure versus conventional clip closure in ESD of large (> 15 mm) nonpedunculated colorectal polyps (LNPCPs) - Takeaways - MDSpire

Safety outcomes of mucomuscular closure versus conventional clip closure in ESD of large (> 15 mm) nonpedunculated colorectal polyps (LNPCPs)

  • By

  • T.‐Y. Chen

  • L.-F. Wu

  • X.-Y. Xu

  • Y.-B. Liu

  • Y.-F. Zhang

  • W.‐F. Chen

  • Q.‐L. Li

  • J.‐W. Hu

  • J.-X. Xu

  • J. Cheng

  • K.-Q. Zhou

  • P.-H. Zhou

  • Y.‐Q. Zhang

  • December 24, 2025

  • 0 min

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  • 1

    Mucomuscular closure significantly reduces the incidence of post-endoscopic submucosal dissection electrocoagulation syndrome compared to conventional closure.

  • 2

    The study included 764 patients, showing a PEECS incidence of 2.5% in the mucomuscular closure group versus 15.0% in the conventional group.

  • 3

    No severe adverse events occurred in the mucomuscular closure group, while the conventional group experienced delayed perforation and bleeding.

  • 4

    The occurrence of PEECS was similar in complete and partial closure cases within the mucomuscular closure group.

  • 5

    Mucomuscular closure with through-the-scope clips is effective in preventing postoperative complications after colorectal ESD.

Original Source(s)

Safety outcomes of mucomuscular closure versus conventional clip closure in ESD of large (> 15 mm) nonpedunculated colorectal polyps (LNPCPs)

  • by T.‐Y. Chen, L.-F. Wu, X.-Y. Xu, Y.-B. Liu, Y.-F. Zhang, W.‐F. Chen, Q.‐L. Li, J.‐W. Hu, J.-X. Xu, J. Cheng, K.-Q. Zhou, P.-H. Zhou, Y.‐Q. Zhang

  • December 24, 2025

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