Assessment of the Safety and Effectiveness of Stem Cell Treatments for Dry Eye Syndrome Associated with Sjögren’s Syndrome: A Systematic Review and Meta-Analysis - Takeaways - MDSpire
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Assessment of the Safety and Effectiveness of Stem Cell Treatments for Dry Eye Syndrome Associated with Sjögren’s Syndrome: A Systematic Review and Meta-Analysis

  • By

  • Jizhong Zhang

  • Wenshuang Wang

  • Changyong Li

  • April 29, 2026

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  • 1

    Stem cell therapy shows promise in treating dry eye syndrome associated with Sjögren’s syndrome, though it lacks clinical approval.

  • 2

    The meta-analysis included five studies with 114 patients, demonstrating significant improvements in OSDI and Schirmer test scores post-treatment.

  • 3

    Adverse events included injection pain, ocular discomfort, and blurred vision, with varying incidence rates observed at 4 weeks.

  • 4

    Results indicated a significant reduction in OSDI scores by -15.10 and an increase in NIKBUT first scores by 3.26 post-treatment.

  • 5

    The findings suggest careful consideration of benefits and risks is essential before clinical application of stem cell therapies.

Original Source(s)

Assessment of the Safety and Effectiveness of Stem Cell Treatments for Dry Eye Syndrome Associated with Sjögren’s Syndrome: A Systematic Review and Meta-Analysis

  • by Jizhong Zhang, Wenshuang Wang, Changyong Li

  • April 29, 2026

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