Clinical characteristics and outcomes in leptomeningeal disease with or without brain metastasis: insights from an explorative data analysis of the Charité LMD registry - Takeaways - MDSpire

Clinical characteristics and outcomes in leptomeningeal disease with or without brain metastasis: insights from an explorative data analysis of the Charité LMD registry

  • By

  • David Wasilewski

  • Chiara Eitner

  • Rober Ates

  • Selin Murad

  • Zoe Shaked

  • Julia Alexandra Steinle

  • Andreas Wetzel-Yalelis

  • Tarik Alp Sargut

  • Judith Rösler

  • Majd Abdulhamid Samman

  • Peter Truckenmüller

  • Robert Mertens

  • Daniel Kroneberg

  • Alexander Kowski

  • Helena Radbruch

  • David Capper

  • Felix Ehret

  • Siyer Roohani

  • Nikolaj Frost

  • Jawed Nawabi

  • Julia Onken

  • Maximilian Schlaak

  • Jens-Uwe Blohmer

  • Uwe Pelzer

  • Ulrich Keller

  • Jalid Sehouli

  • Peter Vajkoczy

  • Ulrich Keilholz

  • Martin Misch

  • February 11, 2025

  • 0 min

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  • 1

    Leptomeningeal disease (LMD) is a late-stage complication of metastatic malignancies, leading to significant morbidity and poor prognosis.

  • 2

    Common tumors associated with LMD include breast cancer, non-small cell lung cancer, and melanoma, with LMD affecting up to 37% of brain metastasis patients.

  • 3

    Diagnosis of LMD typically involves cranial and spinal MRI, CSF sampling, or biopsy, with incidence rising due to improved cancer therapies.

  • 4

    This study aims to analyze clinical characteristics and prognostic factors in LMD patients, focusing on intracranial and extracranial disease burden.

  • 5

    Statistical analyses were performed to summarize patient data and estimate median overall survival using Kaplan-Meier analysis and Cox regression.

Original Source(s)

Clinical characteristics and outcomes in leptomeningeal disease with or without brain metastasis: insights from an explorative data analysis of the Charité LMD registry

  • by David Wasilewski, Chiara Eitner, Rober Ates, Selin Murad, Zoe Shaked, Julia Alexandra Steinle, Andreas Wetzel-Yalelis, Tarik Alp Sargut, Judith Rösler, Majd Abdulhamid Samman, Peter Truckenmüller, Robert Mertens, Daniel Kroneberg, Alexander Kowski, Helena Radbruch, David Capper, Felix Ehret, Siyer Roohani, Nikolaj Frost, Jawed Nawabi, Julia Onken, Maximilian Schlaak, Jens-Uwe Blohmer, Uwe Pelzer, Ulrich Keller, Jalid Sehouli, Peter Vajkoczy, Ulrich Keilholz, Martin Misch

  • February 11, 2025

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