MIR4435-2HG: A Crucial Component in New lncRNA Prognostic Signatures Linked to Early Metastasis and Adverse Outcomes Following Tumor Resection in Esophageal Squamous Cell Carcinoma - Takeaways - MDSpire

MIR4435-2HG: A Crucial Component in New lncRNA Prognostic Signatures Linked to Early Metastasis and Adverse Outcomes Following Tumor Resection in Esophageal Squamous Cell Carcinoma

  • By

  • Pengju Qi

  • Shuhua Huo

  • Wenchao Wu

  • Tengfei Zhang

  • Wenqian Yang

  • Jiaping Tang

  • Yuzhen Liu

  • Baosheng Zhao

  • November 24, 2025

  • 0 min

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  • 1

    Esophageal cancer (ESCA) is a leading cause of cancer incidence and mortality, with squamous cell carcinoma (ESCC) being the predominant type in China.

  • 2

    Tumor metastasis significantly impacts the prognosis of ESCC patients, highlighting the need for identifying metastasis-related biomarkers.

  • 3

    LncRNA plays a vital role in tumor progression and may serve as potential biomarkers for diagnosis and prognosis in ESCC.

  • 4

    The study identified metastasis-susceptibility related lncRNAs (MESUlncs) through RNA-seq analysis of ESCC tumor tissues with differing prognoses.

  • 5

    MIR4435-2HG was identified as a key biomarker associated with early postoperative metastasis and poor prognosis in ESCC patients.

Original Source(s)

MIR4435-2HG: A Crucial Component in New lncRNA Prognostic Signatures Linked to Early Metastasis and Adverse Outcomes Following Tumor Resection in Esophageal Squamous Cell Carcinoma

  • by Pengju Qi, Shuhua Huo, Wenchao Wu, Tengfei Zhang, Wenqian Yang, Jiaping Tang, Yuzhen Liu, Baosheng Zhao

  • November 24, 2025

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