Surgical outcomes of Bethesda System for Reporting Thyroid Cytopathology diagnostic category class I, II, and III thyroid nodules - Takeaways - MDSpire

Surgical outcomes of Bethesda System for Reporting Thyroid Cytopathology diagnostic category class I, II, and III thyroid nodules

  • By

  • Sang-Wook Park

  • Ga Young Lee

  • Min Ji Kim

  • Minsu Kwon

  • Young Ho Jung

  • Seung-Ho Choi

  • Dong Eun Song

  • Yoon Se Lee

  • May 25, 2026

  • 0 min

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  • 1

    Surgery is recommended for Bethesda classes I–III thyroid nodules only in specific situations, such as large tumors or clinical suspicion of malignancy.

  • 2

    In a study of 192 patients, carcinoma was confirmed in 32.3%, with malignancy rates of 23.5%, 20.4%, and 49.4% for Bethesda classes I, II, and III, respectively.

  • 3

    Bethesda class III nodules had a significantly higher incidence of malignancy, with larger nodule size and atypia as risk factors for malignancy.

  • 4

    Atypia with nuclear and architectural features (AUS-N/A) was identified as an independent predictor of malignancy in Bethesda class III nodules.

  • 5

    Despite confirmed carcinoma in some cases, the probability of recurrence after surgery for Bethesda classes I, II, and III is low, indicating a favorable prognosis.

Original Source(s)

Surgical outcomes of Bethesda System for Reporting Thyroid Cytopathology diagnostic category class I, II, and III thyroid nodules

  • by Sang-Wook Park, Ga Young Lee, Min Ji Kim, Minsu Kwon, Young Ho Jung, Seung-Ho Choi, Dong Eun Song, Yoon Se Lee

  • May 25, 2026

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