Imaging features and differentiation between benign and malignant Brenner tumors in a multi-center cohort

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The study analyzed imaging features of ovarian Brenner tumors to improve differential diagnosis between benign and malignant variants.
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Elevated serum CA125 levels were significantly more common in borderline/malignant Brenner tumors compared to benign cases.
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Key imaging characteristics differentiating tumor types included maximum diameter, papillary projections, and venous-phase CT net enhancement.
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The combined model for distinguishing tumor types showed a promising discriminative ability with an AUC of 0.956.
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Identifying independent risk factors can enhance preoperative imaging assessment and risk categorization of Brenner tumors.

Frontiers In Oncology

by Tao Zhou, Peng Xia, Qinghai Miao, Li Li, Libin Cao, Zhongqiu Wang, Zefeng Shao, Na Duan
June 12, 2026

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