Development and validation of a predictive model for chronic or persistent immune thrombocytopenia in children incorporating anti-glycoprotein IIb antibody: a retrospective cohort study utilizing LASSO regression and bootstrap stability analysis - Takeaways - MDSpire

Development and validation of a predictive model for chronic or persistent immune thrombocytopenia in children incorporating anti-glycoprotein IIb antibody: a retrospective cohort study utilizing LASSO regression and bootstrap stability analysis

  • By

  • Ximei Yang

  • Xianghui Wan

  • Lei Ying

  • Xiaoying Chen

  • Zhiqiang Liu

  • Wei Huang

  • Jiangwei Ke

  • June 5, 2026

  • 0 min

Share

  • 1

    The study developed a predictive model for chronic immune thrombocytopenia (cITP) in pediatric patients using clinical factors and anti-GPIIb antibodies.

  • 2

    A total of 381 children with newly diagnosed ITP were analyzed, with 266 in the training set and 115 in the test set.

  • 3

    Fourteen stable predictors were identified, with platelet count, recent infection or vaccination history, and anti-GPIIb antibody status being the most significant.

  • 4

    The final model demonstrated good discrimination in the test set with an AUC of 0.743 and satisfactory calibration (P = 0.859).

  • 5

    The model's negative predictive value reached 94.7% at a low-risk threshold, aiding in the identification of children unlikely to develop cITP.

Original Source(s)

Development and validation of a predictive model for chronic or persistent immune thrombocytopenia in children incorporating anti-glycoprotein IIb antibody: a retrospective cohort study utilizing LASSO regression and bootstrap stability analysis

  • by Ximei Yang, Xianghui Wan, Lei Ying, Xiaoying Chen, Zhiqiang Liu, Wei Huang, Jiangwei Ke

  • June 5, 2026

Related Content

This Week’s CGT News: New FDA Genome Editing Guidance 

Our latest roundup highlights tighter FDA expectations for genome editing safety, advances in CRISPR precision and delivery, and continued momentum for off-the-shelf CAR-T

  • April 20, 2026

  • 6 min
Partly intraoperative cell salvage in pediatric craniocerebral trauma: effects on coagulation function, allogeneic blood requirements, and clinical outcomes — a propensity score-matched retrospective cohort study

Colorectal Cancer Treatment During Pregnancy

Colorectal cancer (CRC) impacts about 1 in 13,000 pregnancies in the United States. This article follows the case of a 36-year-old woman diagnosed with CRC while pregnant and highlights considerations around CRC diagnosis and cancer treatment during pregnancy.