Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD+ - Takeaways - MDSpire

Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD+

  • By

  • Maria J Lagartos-Donate

  • Beatriz Escobar-Doncel

  • Shi-qi Zhang

  • Jun-ping Pan

  • Noemí Villaseca González

  • Alexander Anisimov

  • Nicola P Montaldo

  • Vidar Jensen

  • Lipeng Mao

  • Bailei Li

  • Nuria Banzon-Pereira

  • Liu Shi

  • Shu-qin Cao

  • Domenica Caponio

  • Pingjie Wang

  • Rajeevkumar Raveendran Nair

  • Oscar Junhong Luo

  • Guobing Chen

  • Alejo J Nevado-Holgado

  • Noel Buckley

  • Hilde Loge Nilsen

  • Evandro Fei Fang

  • February 19, 2026

  • 0 min

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  • 1

    Decreased levels of REST are associated with Alzheimer's disease pathology, contributing to cognitive decline and neurodegeneration.

  • 2

    REST overexpression improves cognitive function and reduces amyloid-β and phosphorylated Tau deposition in Alzheimer's disease.

  • 3

    The NAD+/SIRT1 axis modulates REST expression, influencing mitophagy and synaptic function through chromatin remodeling.

  • 4

    NAD+ supplementation enhances SIRT1 levels, restoring mitophagy and reducing Alzheimer's-related pathologies and memory loss.

  • 5

    REST is identified as a promising therapeutic target for Alzheimer's disease, highlighting its role in neuroprotection and healthy aging.

Original Source(s)

Loss of REST associated with Alzheimer's disease pathology is ameliorated by NAD+

  • by Maria J Lagartos-Donate, Beatriz Escobar-Doncel, Shi-qi Zhang, Jun-ping Pan, Noemí Villaseca González, Alexander Anisimov, Nicola P Montaldo, Vidar Jensen, Lipeng Mao, Bailei Li, Nuria Banzon-Pereira, Liu Shi, Shu-qin Cao, Domenica Caponio, Pingjie Wang, Rajeevkumar Raveendran Nair, Oscar Junhong Luo, Guobing Chen, Alejo J Nevado-Holgado, Noel Buckley, Hilde Loge Nilsen, Evandro Fei Fang

  • February 19, 2026

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