Prognostic relevance of resection at first recurrence in isocitrate dehydrogenase mutant lower-grade glioma: results from a retrospective, single-center, volumetric analysis

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IDH-mutant lower-grade gliomas include WHO grade 2 and 3 tumors, which have favorable prognoses compared to other glioma subtypes.
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Maximal safe surgical resection at initial diagnosis is crucial for long-term tumor control in IDH-mutant gliomas.
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The study analyzed 148 patients with recurrent IDH-mutant gliomas to evaluate the impact of surgical resection at first recurrence.
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Repeat surgical resection may alleviate symptoms and guide treatment, but its survival benefit remains debated due to previous study limitations.
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The findings aim to clarify the role of surgical intervention at recurrence and its association with progression-free and overall survival.

Journal Of Neuro-Oncology (Springer)

by Christine Jungk, Karla Goepfert, Mara Gluszak, Karim Marhaba, Philip Dao Trong, Sandro M. Krieg, Martin Bendszus, Felix Sahm, Andreas W. Unterberg
March 11, 2026

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