Risk factors, subtype profiles, and outcomes of cardiac rupture after acute myocardial infarction: a case-control study - Takeaways - MDSpire

Risk factors, subtype profiles, and outcomes of cardiac rupture after acute myocardial infarction: a case-control study

  • By

  • Dan Zhang

  • Chaojie Huang

  • Xiaosu Wang

  • Jingdan Yu

  • Litao Zhang

  • Bo Liu

  • June 10, 2026

  • 0 min

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  • 1

    Cardiac rupture (CR) following acute myocardial infarction (AMI) has a mortality rate exceeding 50%, necessitating early identification of high-risk patients.

  • 2

    In a study of 71 CR patients, factors like absence of emergency PCI, Killip class III–IV, female sex, and lower serum albumin were linked to CR.

  • 3

    Free wall rupture (FWR) had a significantly higher mortality rate (97.4%) compared to ventricular septal rupture (VSR) at 57.1%.

  • 4

    Early rupture (≤3 days) was associated with higher inflammatory markers, while late rupture (>3 days) correlated with lower albumin and delayed presentation.

  • 5

    Surgical repair was the only factor linked to reduced in-hospital mortality among CR patients, highlighting the need for prompt multidisciplinary evaluation.

Original Source(s)

Risk factors, subtype profiles, and outcomes of cardiac rupture after acute myocardial infarction: a case-control study

  • by Dan Zhang, Chaojie Huang, Xiaosu Wang, Jingdan Yu, Litao Zhang, Bo Liu

  • June 10, 2026

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