Limonin Reduces Pyroptosis and Inflammation in Myocardial Ischemia-Reperfusion Mice by Targeting the Caspase-3/GSDME Pathway - Takeaways - MDSpire

Limonin Reduces Pyroptosis and Inflammation in Myocardial Ischemia-Reperfusion Mice by Targeting the Caspase-3/GSDME Pathway

  • By

  • Jianlong Li

  • Zhe Li

  • Pengran Wang

  • Zhian Jiang

  • April 29, 2026

  • 0 min

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  • 1

    Limonin, a natural compound from citrus fruits, exhibits anti-inflammatory and antioxidant properties beneficial for myocardial ischemia-reperfusion injury.

  • 2

    The study demonstrated that limonin significantly reduces pyroptosis and inflammatory responses in myocardial cells during ischemia-reperfusion injury.

  • 3

    Limonin's protective effects are mediated through the inhibition of the caspase-3/GSDME pathway, which is crucial in regulating pyroptosis.

  • 4

    In vivo experiments showed that limonin pretreatment improved cardiac function and reduced myocardial tissue damage in mice with ischemia-reperfusion injury.

  • 5

    This research provides a theoretical basis for developing limonin-based strategies to protect against myocardial ischemia-reperfusion injury.

Original Source(s)

Limonin Reduces Pyroptosis and Inflammation in Myocardial Ischemia-Reperfusion Mice by Targeting the Caspase-3/GSDME Pathway

  • by Jianlong Li, Zhe Li, Pengran Wang, Zhian Jiang

  • April 29, 2026

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