Swimming ameliorates intervertebral disc degeneration accompanied by Rpl23a downregulation and changes in its immune-inflammatory pathway - Takeaways - MDSpire

Swimming ameliorates intervertebral disc degeneration accompanied by Rpl23a downregulation and changes in its immune-inflammatory pathway

  • By

  • Yong Ji

  • Haixin Ma

  • Rong Tan

  • Xin Sha

  • Xin Li

  • June 2, 2026

  • 0 min

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  • 1

    Rpl23a is significantly upregulated in degenerated intervertebral discs and primarily expressed in fibroblasts.

  • 2

    Rpl23a overexpression increases TNF-α and IL-1β secretion, activates NF-κB signaling, and induces cell apoptosis.

  • 3

    Swimming alleviates intervertebral disc degeneration in rats, reducing Rpl23a expression and immune cell infiltration.

  • 4

    Rpl23a is implicated in the formation of a pro-inflammatory microenvironment in intervertebral disc degeneration.

  • 5

    The study suggests that Rpl23a may mediate the protective effects of exercise on intervertebral discs.

Original Source(s)

Swimming ameliorates intervertebral disc degeneration accompanied by Rpl23a downregulation and changes in its immune-inflammatory pathway

  • by Yong Ji, Haixin Ma, Rong Tan, Xin Sha, Xin Li

  • June 2, 2026

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