Crucial role of IL-6, IL-8, IL-11 and leptin in tumor microenvironment in a group of patients with GEP-NETs- crosstalk between inflammation and cancer - Takeaways - MDSpire

Crucial role of IL-6, IL-8, IL-11 and leptin in tumor microenvironment in a group of patients with GEP-NETs- crosstalk between inflammation and cancer

  • By

  • Agata Świętek

  • Joanna K. Strzelczyk

  • Dorota Hudy

  • Zenon P. Czuba

  • Karolina Snopek-Miśta

  • Mariusz Kryj

  • Katarzyna Kuśnierz

  • Marcin Zeman

  • Malgorzata Oczko-Wojciechowska

  • Daria Handkiewicz-Junak

  • Janusz Strzelczyk

  • July 2, 2026

  • 0 min

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  • 1

    This study analyzed IL-6, IL-8, IL-11, and leptin levels in tumor and surgical margin samples from 59 patients with GEP-NETs.

  • 2

    Higher concentrations of IL-6, IL-8, IL-11, and leptin were found in tumor samples compared to corresponding surgical margins.

  • 3

    Elevated IL-6 and leptin levels were significantly associated with advanced tumor stages, particularly T4 and M1.

  • 4

    Cytokine levels varied by tumor localization, with distinct patterns observed among pancreatic, ileal, colonic, and small intestine tumors.

  • 5

    The study highlights the association of cytokines with comorbidities and socio-demographic factors, including body mass and smoking.

Original Source(s)

Crucial role of IL-6, IL-8, IL-11 and leptin in tumor microenvironment in a group of patients with GEP-NETs- crosstalk between inflammation and cancer

  • by Agata Świętek, Joanna K. Strzelczyk, Dorota Hudy, Zenon P. Czuba, Karolina Snopek-Miśta, Mariusz Kryj, Katarzyna Kuśnierz, Marcin Zeman, Malgorzata Oczko-Wojciechowska, Daria Handkiewicz-Junak, Janusz Strzelczyk

  • July 2, 2026

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