Human neutrophils recognize group B streptococci via formylated peptide receptors and toll-like receptor 8

1

Human neutrophils play a crucial role in defending against group B Streptococcus (GBS), a pathogen causing severe infections.
2

Neutrophils secrete pro-inflammatory cytokines and reactive oxygen species in response to live GBS, primarily through formyl peptide receptors.
3

Formyl peptide receptors 1 and 2 (FPR1 and FPR2) are essential for neutrophil chemotaxis and ROS production in response to live GBS.
4

Toll-like receptor 8 (TLR8) is critical for recognizing both live and inactivated GBS by detecting bacterial RNA.
5

The study reveals a three-part sensing mechanism involving TLR8, FPR1, and FPR2 that enhances neutrophil responses to GBS.

Frontiers In Immunology

by Luigi Fiore, Giuseppe Valerio De Gaetano, Federica Grasso, Francesco Coppolino, Agata Famà, Mariachiara Stifano, Annamaria Petrungaro, Federica Vita, Eugenia Quartarone, Chiara Cipollina, Germana Lentini, Concetta Beninati
May 4, 2026

1