Preoperative electrolyte-based metabolic biomarkers for prognostic assessment in gastric cancer: a multicenter study

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A multicenter study identified sodium and calcium as independent prognostic factors for overall survival in gastric cancer patients.
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The Electrolyte Score, based on sodium and calcium levels, stratified patients into distinct risk groups in both training and validation cohorts.
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Higher levels of sodium and calcium were associated with better survival outcomes in gastric cancer patients.
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Combining the Electrolyte Score with clinicopathological variables improved individualized prognostic predictions for gastric cancer.
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The study highlights the potential of preoperative electrolyte-based scores as practical tools for risk stratification in clinical practice.

Frontiers In Endocrinology

by Weihao Kong, Jiawen Wang, Xuqin Wu, Kangjie Zhang, Xingyu Wang, Jianlin Zhang
June 11, 2026

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