Effect and mechanism of repetitive transcranial magnetic stimulation of angular gyrus on patients with consciousness disorder - Takeaways - MDSpire

Effect and mechanism of repetitive transcranial magnetic stimulation of angular gyrus on patients with consciousness disorder

  • By

  • Linghui Dong

  • Hui Li

  • Kaiyue Han

  • Zhiqing Tang

  • Xingxing Liao

  • Junzi Long

  • Xinyue Liu

  • Tao Lin

  • Hao Zhang

  • June 17, 2026

  • 0 min

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  • 1

    High-frequency rTMS of the left angular gyrus improved behavioral signs of consciousness in patients with prolonged disorders of consciousness.

  • 2

    The study utilized a randomized, double-blind, sham-controlled crossover trial design with 40 patients completing the trial.

  • 3

    Behavioral improvements were more frequent during active rTMS compared to sham stimulation, particularly in visual, motor, and auditory domains.

  • 4

    Post-rTMS recovery within the default mode network and subcortical network characterized responders, with strong baseline connectivity predicting improvement.

  • 5

    The findings suggest that rTMS may facilitate consciousness recovery through network reconfiguration in patients with pDoC.

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