Efficacy of a novel device for cryoprevention of oral mucositis: a randomized, blinded, multicenter, parallel group, phase 3 trial - Takeaways - MDSpire

Efficacy of a novel device for cryoprevention of oral mucositis: a randomized, blinded, multicenter, parallel group, phase 3 trial

  • By

  • Java Walladbegi

  • Roger Henriksson

  • Björn Tavelin

  • Anncarin Svanberg

  • Gunnar Larfors

  • Martin Jädersten

  • Fredrik Schjesvold

  • Aram Mahdi

  • Karin Garming Legert

  • Douglas E. Peterson

  • Mats Jontell

  • November 3, 2021

  • 0 min

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  • 1

    Oral mucositis affects up to 80% of patients undergoing high-dose chemotherapy with hematopoietic stem cell transplantation.

  • 2

    Cryotherapy using ice chips is a common preventive method for chemotherapy-induced oral mucositis, promoting vasoconstriction.

  • 3

    This study is the first randomized trial comparing conventional ice therapy with an intraoral cooling device for oral mucositis prevention.

  • 4

    Patients were randomly assigned to receive either ice chips or the intraoral cooling device prior to chemotherapy sessions.

  • 5

    The degree of oral mucositis was assessed using the Oral Mucositis Assessment Scale, with high inter-rater reliability confirmed.

Original Source(s)

Efficacy of a novel device for cryoprevention of oral mucositis: a randomized, blinded, multicenter, parallel group, phase 3 trial

  • by Java Walladbegi, Roger Henriksson, Björn Tavelin, Anncarin Svanberg, Gunnar Larfors, Martin Jädersten, Fredrik Schjesvold, Aram Mahdi, Karin Garming Legert, Douglas E. Peterson, Mats Jontell

  • November 3, 2021

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