Human NKT10 cells are enriched in cord-derived invariant natural killer T cells and mediate immune-regulation in a xenogeneic graft-versus-host disease model - Takeaways - MDSpire

Human NKT10 cells are enriched in cord-derived invariant natural killer T cells and mediate immune-regulation in a xenogeneic graft-versus-host disease model

  • By

  • Abel Trujillo-Ocampo

  • Pamella Borges

  • Maison Grefe

  • Martiela Vaz de Freitas

  • Sung-Eun Lee

  • Yuan Qi

  • Jelita Clinton

  • Dan Li

  • Hong He

  • Ling Yu

  • Arnau Peris-Cuesta

  • Erik A. Ehli

  • Qing Ma

  • Xiaoping Su

  • Dinler Amaral Antunes

  • Gheath Al-Atrash

  • Jeffrey J. Molldrem

  • Elizabeth J. Shpall

  • Jin S. Im

  • June 10, 2026

  • 0 min

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  • 1

    NKT10 cells, a subset of invariant natural killer T cells, are characterized by their IL-10 production and potential immunoregulatory roles.

  • 2

    Cord-derived iNKT cells exhibit a high frequency of CD4+CD25+CD161lowFoxP3+ iNKT cells and show Th2/Th10-biased cytokine production.

  • 3

    Single-cell RNA sequencing revealed that cord-derived iNKT cells have an enriched NKT10-like subset with multiple immunoregulatory pathways.

  • 4

    Cord-derived iNKT cells demonstrated the ability to suppress alloreactive T cell proliferation and ameliorate xenogeneic graft-versus-host disease.

  • 5

    NKT10-enriched, cord-derived iNKT cells are proposed as candidate cell therapeutics for immune modulation in allogeneic stem cell transplantation.

Original Source(s)

Human NKT10 cells are enriched in cord-derived invariant natural killer T cells and mediate immune-regulation in a xenogeneic graft-versus-host disease model

  • by Abel Trujillo-Ocampo, Pamella Borges, Maison Grefe, Martiela Vaz de Freitas, Sung-Eun Lee, Yuan Qi, Jelita Clinton, Dan Li, Hong He, Ling Yu, Arnau Peris-Cuesta, Erik A. Ehli, Qing Ma, Xiaoping Su, Dinler Amaral Antunes, Gheath Al-Atrash, Jeffrey J. Molldrem, Elizabeth J. Shpall, Jin S. Im

  • June 10, 2026

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