The role of sortilin in cardiovascular calcification: mechanisms and therapeutic potential - Takeaways - MDSpire

The role of sortilin in cardiovascular calcification: mechanisms and therapeutic potential

  • By

  • Yaqing Yao

  • Sijia Li

  • Shuangshuang Wang

  • June 10, 2026

  • 0 min

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  • 1

    Cardiovascular calcification is an actively regulated process linked to metabolic risk factors like dyslipidemia, diabetes, and hypertension.

  • 2

    Sortilin, encoded by SORT1, is a key molecular mediator connecting metabolic disorders to pro-calcific cellular responses.

  • 3

    Elevated plasma sortilin levels are associated with hypertension and may serve as a biomarker for cardiovascular risk.

  • 4

    Sortilin disrupts sphingolipid/ceramide homeostasis, inducing oxidative stress and contributing to vascular damage in hypertension.

  • 5

    Dyslipidemia is a critical factor in cardiovascular calcification, with sortilin playing a complex role in its pathogenesis.

Original Source(s)

The role of sortilin in cardiovascular calcification: mechanisms and therapeutic potential

  • by Yaqing Yao, Sijia Li, Shuangshuang Wang

  • June 10, 2026

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