Revealing Neurosarcoidosis in a Patient with Acute Zonal Occult Outer Retinopathy: A Case Study - Takeaways - MDSpire

Revealing Neurosarcoidosis in a Patient with Acute Zonal Occult Outer Retinopathy: A Case Study

  • By

  • Inês Coelho-Costa

  • Rita Rodrigues

  • Amândio Rocha-Sousa

  • Susana Penas

  • Luís Figueira

  • Sónia Torres-Costa

  • January 29, 2026

  • 0 min

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  • 1

    Neurosarcoidosis (NS) is a rare form of systemic sarcoidosis affecting the nervous system, with ocular involvement in up to one-third of cases.

  • 2

    A 37-year-old woman presented with bilateral panuveitis and optic disc edema, raising suspicion for an underlying condition despite her history of AZOOR.

  • 3

    Elevated angiotensin-converting enzyme levels and imaging revealed non-caseating granulomatous inflammation, confirming a diagnosis of sarcoidosis.

  • 4

    The patient was treated with corticosteroids and methotrexate, leading to significant clinical improvement and resolution of neurological symptoms.

  • 5

    Diagnosing NS can be challenging; it should be considered in patients with neurological symptoms, especially those with known sarcoidosis.

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