Sudden Death Trajectories in HFpEF, HFmrEF
Clinical changes before death overlap across outcomes
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By
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Kathryn Wighton
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March 31, 2026
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1
Sudden death in HFpEF and HFmrEF patients was preceded by modest worsening in functional status and symptom burden.
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2
In the FINEARTS-HF trial, 215 sudden deaths occurred among 6,001 patients over a median follow-up of 2.7 years.
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3
Patients who experienced sudden death showed slight worsening in NYHA class and increased NT-proBNP levels in the months prior.
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4
Current guidelines do not recommend implantable cardioverter-defibrillators for primary prevention due to risk stratification limitations.
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The study's findings suggest that observed trajectories may indicate overall risk rather than specific sudden death prevention.
