Prognosis and recovery trajectories in prolonged disorders of consciousness: protocol for the PDOCC 5-year prospective cohort study

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The PDOCC study investigates 5-year outcomes in 1,000 patients with prolonged disorders of consciousness at Guangdong Sanjiu Brain Hospital.
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Primary outcomes include consciousness recovery, all-cause mortality, and major cardiovascular events assessed over 5 years.
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The study employs standardized clinical assessments, neuroimaging, and biomarkers to evaluate patient outcomes.
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Competing-risk models will be used to analyze time-to-event data, accounting for mortality as a competing event.
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The study aims to develop a multimodal prognostic prediction model to inform rehabilitation decision-making.

Frontiers In Neurology

by Hanbo Chen, Yong Luo, Weifeng Wen, Yunhong Deng, Zeyue Wen, Shujuan Huang, Li Qin, Si Chen, Xiao Lu
July 13, 2026

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