Ankylosing spondylitis and the gut microbiome: future research hotspots and trends

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Ankylosing spondylitis (AS) is an autoimmune disease influenced by genetic, environmental factors, and gut microbiota.
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Research indicates a significant relationship between gut microbiota and AS, suggesting gut dysbiosis may drive the disease.
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China and the USA are the leading contributors to AS and gut microbiome research, with a notable increase in publication volume.
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Current research hotspots include inflammation, HLA-B27, probiotics, and the role of short-chain fatty acids in AS.
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Future studies should focus on causal mechanisms and multi-omics analysis to better understand the gut-joint axis in AS.

Frontiers In Immunology

by Xingxiao Yin, Hao Peng, Yanqi Li, Yanping Song, Na Yao, Zhen Shen, Hongbo Chen, Li Huang, Pengcheng Li, Zhijuan He, Qigang Chen
May 5, 2026

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