Noninvasive Diagnosis of Splenosis Using Tc-99m Heat-Denatured Red Blood Cell Scintigraphy - Takeaways - MDSpire
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Noninvasive Identification of Splenosis Through Tc-99m Scintigraphy with Heat-Denatured Red Blood Cells

  • By

  • Natacha Dewarrat

  • Katharina Auf der Springe

  • Francesco Grandoni

  • Rami Hajri

  • Mathilde Gavillet

  • September 9, 2026

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  • 1

    A 23-year-old patient with hereditary spherocytosis underwent evaluation for abdominal masses after splenectomy.

  • 2

    Blood tests showed post-splenectomy patterns, including reticulocytosis and thrombocytosis, with undetectable haptoglobin.

  • 3

    Differential diagnosis for the masses included splenosis and lymphoma, with biopsy recommended due to hemorrhagic risk.

  • 4

    Selective splenic scintigraphy with technetium-99 m-labeled red blood cells confirmed splenosis by revealing intense tracer accumulation.

  • 5

    The study illustrates that SPECT/CT can noninvasively diagnose splenosis, reducing the need for biopsy and bleeding risk.

Original Source(s)

Noninvasive Diagnosis of Splenosis Using Tc-99m Heat-Denatured Red Blood Cell Scintigraphy

  • by Natacha Dewarrat, Katharina Auf der Springe, Francesco Grandoni, Rami Hajri, Mathilde Gavillet

  • September 9, 2026

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