Digitally Assessed Long COVID Symptomatology Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential - Takeaways - MDSpire

Digitally Assessed Long COVID Symptomatology Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential

  • By

  • Vasile Mihai Sularea

  • Liam Townsend

  • Cian Reid

  • Andreea V Atanasescu

  • Adam H Dyer

  • Federica Giangrazi

  • Roman Rocha Lawrence

  • Manoj Sivan

  • Barry Moran

  • Derek G Doherty

  • Niall P Conlon

  • Aideen Long

  • Cliona O’Farrelly

  • November 17, 2025

  • 0 min

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  • 1

    Long COVID affects 3% to 10% of COVID-19 survivors, with symptoms like fatigue, cognitive dysfunction, and dysautonomia persisting for months.

  • 2

    Patients with long COVID show significant mitochondrial dysfunction in immune cells, correlating with symptom severity and specific clinical features.

  • 3

    Decreased mitochondrial membrane potential in CD56bright natural killer cells is linked to dizziness, while CD4+ lymphocyte dysfunction relates to breathlessness.

  • 4

    Impaired cytokine responses, including lower IFN-γ and altered IL-10 production, are associated with worsening cough and cognitive issues in long COVID patients.

  • 5

    The modified COVID-19 Yorkshire Rehabilitation Scale is utilized to quantify long COVID symptoms, aiding in remote patient assessment and management.

Original Source(s)

Digitally Assessed Long COVID Symptomatology Is Associated With Lymphocyte Mitochondrial Dysfunction and Altered Immune Potential

  • by Vasile Mihai Sularea, Liam Townsend, Cian Reid, Andreea V Atanasescu, Adam H Dyer, Federica Giangrazi, Roman Rocha Lawrence, Manoj Sivan, Barry Moran, Derek G Doherty, Niall P Conlon, Aideen Long, Cliona O’Farrelly

  • November 17, 2025

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