Comparison of efficacy and safety between long-acting growth hormone and short-acting growth hormone in isolated growth hormone deficiency: a systematic review and meta-analysis of 16 randomized controlled trials involving 2,435 pediatric patients - Takeaways - MDSpire

Comparison of efficacy and safety between long-acting growth hormone and short-acting growth hormone in isolated growth hormone deficiency: a systematic review and meta-analysis of 16 randomized controlled trials involving 2,435 pediatric patients

  • By

  • Zhen-Zhen Shen

  • Yun Huang

  • Li-Li Wu

  • Jian-Su Zhang

  • Xiao-Xia Zhang

  • June 4, 2026

  • 0 min

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  • 1

    Long-acting growth hormone (LAGH) shows a statistically significant improvement in height standard deviation score (Ht-SDS) compared to short-acting growth hormone (SA-GH).

  • 2

    LAGH demonstrated superior height velocity standard deviation score (HV-SDS) driven primarily by the PEG-LAGH subgroup in children with isolated growth hormone deficiency (GHD).

  • 3

    Insulin-like growth factor-1 (IGF-1) SDS levels were consistently higher in the LAGH group compared to the SA-GH group across the studies analyzed.

  • 4

    Adverse event rates were similar between LAGH and SA-GH groups, with the PEG-LAGH subgroup exhibiting the lowest incidence of adverse events.

  • 5

    LAGH is preferred for treating pediatric GHD due to its efficacy in height improvement and acceptable safety profile, despite newer formulations lacking superior growth efficacy.

Original Source(s)

Comparison of efficacy and safety between long-acting growth hormone and short-acting growth hormone in isolated growth hormone deficiency: a systematic review and meta-analysis of 16 randomized controlled trials involving 2,435 pediatric patients

  • by Zhen-Zhen Shen, Yun Huang, Li-Li Wu, Jian-Su Zhang, Xiao-Xia Zhang

  • June 4, 2026

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