Psychological distress, but not single-time endocrine stress markers, is associated with unexplained infertility: a prospective case–control study - Takeaways - MDSpire

Psychological distress, but not single-time endocrine stress markers, is associated with unexplained infertility: a prospective case–control study

  • By

  • Sertaç Ayçiçek

  • Berçem Ayçiçek

  • June 26, 2026

  • 0 min

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  • 1

    Women with unexplained infertility exhibited significantly higher anxiety and depression scores compared to age-matched fertile controls.

  • 2

    Psychological distress was present in 76.0% of women with unexplained infertility, compared to 42.3% in the control group.

  • 3

    Single-time serum measurements of cortisol and DHEAS did not show significant differences between women with unexplained infertility and fertile controls.

  • 4

    Psychological distress remained independently associated with unexplained infertility after adjusting for various demographic and hormonal factors.

  • 5

    The study highlights the importance of psychological assessment in women with unexplained infertility, despite limitations in causal inference.

Original Source(s)

Psychological distress, but not single-time endocrine stress markers, is associated with unexplained infertility: a prospective case–control study

  • by Sertaç Ayçiçek, Berçem Ayçiçek

  • June 26, 2026

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