Vitamin D supports activated CD4+ T-cell proliferation through enhanced glutaminolysis - Takeaways - MDSpire

Vitamin D supports activated CD4+ T-cell proliferation through enhanced glutaminolysis

  • By

  • Agustín A. Vera

  • Mauricio Hernandez

  • Ricardo A. Cartes

  • Faryd Llerena

  • Solange E. Cisterna

  • Romina A. Quiroga

  • Sergio A. Sanhueza

  • Camila P. Muñoz-Grez

  • Francisco Vergara

  • Daniel Moena

  • Pablo A. Alarcón

  • Rafael Burgos

  • Coralia I. Rivas

  • Elena Uribe

  • Rafael J. Argüello

  • Cristopher Almarza

  • Felix A. Urra

  • Francisco Tapia-Belmonte

  • Luciano Ferrada

  • Liliana I. Lamperti

  • Estefanía Nova-Lamperti

  • June 11, 2026

  • 0 min

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  • 1

    Vitamin D enhances the proliferation of activated CD4+ T cells through increased glutaminolysis, independent of classical glycolytic metabolism.

  • 2

    VitD-treated CD4+ T cells showed increased cell numbers despite reduced glucose uptake and lactate production.

  • 3

    Proteomic analysis indicated elevated expression of glutaminase and glutamate dehydrogenase, supporting enhanced glutamine metabolism.

  • 4

    Pharmacological inhibition of glutamine uptake or glutaminase activity significantly reduced T cell expansion, highlighting glutamine's essential role.

  • 5

    VitD promotes a metabolically restrained but adaptive proliferative state in CD4+ T cells, with prolonged exposure ultimately restricting proliferation.

Original Source(s)

Vitamin D supports activated CD4+ T-cell proliferation through enhanced glutaminolysis

  • by Agustín A. Vera, Mauricio Hernandez, Ricardo A. Cartes, Faryd Llerena, Solange E. Cisterna, Romina A. Quiroga, Sergio A. Sanhueza, Camila P. Muñoz-Grez, Francisco Vergara, Daniel Moena, Pablo A. Alarcón, Rafael Burgos, Coralia I. Rivas, Elena Uribe, Rafael J. Argüello, Cristopher Almarza, Felix A. Urra, Francisco Tapia-Belmonte, Luciano Ferrada, Liliana I. Lamperti, Estefanía Nova-Lamperti

  • June 11, 2026

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