Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes - Takeaways - MDSpire

Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes

  • By

  • Adam Al-Diwani

  • Nicholas M Provine

  • Andrew Murchison

  • Rhiannon Laban

  • Owen J Swann

  • Ivan Koychev

  • Fintan Sheerin

  • Sandro Da Mesquita

  • Amanda Heslegrave

  • Henrik Zetterberg

  • Paul Klenerman

  • Sarosh R Irani

  • October 21, 2024

  • 0 min

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  • 1

    Cervical lymph nodes (CLNs) show increased levels of neurodegenerative biomarkers compared to plasma in humans.

  • 2

    Ultrasound-guided fine needle aspiration is a safe and effective method for sampling CLNs in human participants.

  • 3

    Significantly higher concentrations of pTau181 were found in CLNs, with levels decreasing with age.

  • 4

    The study suggests that CLNs may serve as a minimally invasive site for measuring brain clearance and lymphatic drainage.

  • 5

    This research provides the first evidence of detectable neurodegenerative biomarkers in human CLNs, aiding future clinical trials.

Original Source(s)

Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes

  • by Adam Al-Diwani, Nicholas M Provine, Andrew Murchison, Rhiannon Laban, Owen J Swann, Ivan Koychev, Fintan Sheerin, Sandro Da Mesquita, Amanda Heslegrave, Henrik Zetterberg, Paul Klenerman, Sarosh R Irani

  • October 21, 2024

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