Case series analysis of immunophenotypic evolution during recurrence of low-grade endometrial stromal sarcoma: implications for molecular stability and clinical management - Takeaways - MDSpire

Case series analysis of immunophenotypic evolution during recurrence of low-grade endometrial stromal sarcoma: implications for molecular stability and clinical management

  • By

  • Jing Li

  • Lihong Zhang

  • Tingting Chen

  • June 2, 2026

  • 0 min

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  • 1

    The study analyzed paired primary and recurrent tumor samples of low-grade endometrial stromal sarcoma (LG-ESS) from four patients.

  • 2

    All cases exhibited stable JAZF1 or PHF1 gene rearrangements, indicating molecular stability during tumor recurrence.

  • 3

    Immunophenotypic changes were noted, including loss of progesterone receptor expression and variations in Ki-67 and CD10 levels.

  • 4

    Long-term follow-up is crucial due to the characteristic late recurrence of LG-ESS, with intervals ranging from 3 to 12 years.

  • 5

    Re-evaluation of hormone receptor status at recurrence may inform individualized treatment strategies for LG-ESS patients.

Original Source(s)

Case series analysis of immunophenotypic evolution during recurrence of low-grade endometrial stromal sarcoma: implications for molecular stability and clinical management

  • by Jing Li, Lihong Zhang, Tingting Chen

  • June 2, 2026

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