Diagnostic value of D-dimer in screening for deep vein thrombosis after total joint arthroplasty: a meta-analysis - Takeaways - MDSpire

Diagnostic value of D-dimer in screening for deep vein thrombosis after total joint arthroplasty: a meta-analysis

  • By

  • Xinzhen Ding

  • Hubing Wu

  • Qionglin Huang

  • July 14, 2026

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  • 1

    Deep vein thrombosis (DVT) is a serious complication following total joint arthroplasty (TJA), including total hip and knee arthroplasties.

  • 2

    This meta-analysis included 11 studies with 7,123 patients to evaluate the diagnostic accuracy of D-dimer for detecting DVT after TJA.

  • 3

    The pooled sensitivity and specificity of D-dimer for diagnosing postoperative DVT were 0.76 and 0.86, respectively.

  • 4

    Substantial heterogeneity was observed among studies, primarily due to differences in diagnostic cutoff values for D-dimer.

  • 5

    D-dimer may aid in ruling out DVT when results are negative, but it should not be used as a standalone diagnostic tool.

Original Source(s)

Diagnostic value of D-dimer in screening for deep vein thrombosis after total joint arthroplasty: a meta-analysis

  • by Xinzhen Ding, Hubing Wu, Qionglin Huang

  • July 14, 2026

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