Mechanisms outpacing medicine in autoinflammatory diseases By Ruyue Chen June 17, 2026 0 min Frontiers In Immunology Share Summary Takeaways Listen Insight Report Clinical Scorecard Quiz Top Institutions 1 Autoinflammatory diseases are defined at genetic and pathway levels, but therapeutic predictability has not advanced correspondingly. 2 Monogenic disorders show that molecular diagnosis does not reliably predict treatment outcomes or organ-specific risks. 3 Similar clinical phenotypes can arise from distinct genetic defects, complicating therapeutic decision-making. 4 A genotype-informed treatment approach should consider the dominant inflammatory module and organ-specific disease burden. 5 A phenotype-weighted, organ-prioritized, and time-sensitive framework may improve alignment of therapy with clinical outcomes.
