Trained immunity in inflammatory bone disease: a bibliometric and literature-level text-mining analysis - Takeaways - MDSpire

Trained immunity in inflammatory bone disease: a bibliometric and literature-level text-mining analysis

  • By

  • Zihang Zhao

  • Zihan Liu

  • Liang Guo

  • Teng Pan

  • Ruoyu Wang

  • Yiran Li

  • Yingchao Yin

  • Ruipeng Zhang

  • Zhiyong Hou

  • May 20, 2026

  • 0 min

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  • 1

    Trained immunity is a framework for understanding innate immune reprogramming in chronic inflammatory and immune-mediated disorders.

  • 2

    The study analyzed 83 core and 301 extended records, revealing increasing publication output in trained immunity and inflammatory bone disease.

  • 3

    Periodontitis was identified as the most prominent disease context, with other conditions like osteoarthritis and inflammatory arthritis also highlighted.

  • 4

    Key literature patterns included myeloid-cell reprogramming, epigenetic remodeling, and macrophage-related pathways in inflammatory bone disorders.

  • 5

    Research on trained immunity in inflammatory bone disease is expanding but remains fragmented across various disease contexts.

Original Source(s)

Trained immunity in inflammatory bone disease: a bibliometric and literature-level text-mining analysis

  • by Zihang Zhao, Zihan Liu, Liang Guo, Teng Pan, Ruoyu Wang, Yiran Li, Yingchao Yin, Ruipeng Zhang, Zhiyong Hou

  • May 20, 2026

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