When NPi and QPi diverge: Does QPi provide prognostic value beyond NPi?

1

The prospective, multicentre LYNX study found that NPi and QPi were associated with neurological outcomes, but QPi was more sensitive to anaesthetic exposure.
2

Across 7,089 paired measurements, NPi and QPi were moderately to strongly correlated (r = 0.717), while abnormal measurements were more frequent with QPi than NPi.
3

Separate adjusted models linked each index to unfavourable 6-month neurological outcomes, but did not establish whether QPi adds prognostic information when NPi is normal.
4

Analyses of within-patient discordant readings, particularly abnormal QPi with normal NPi, could assess their frequency, persistence, and association with later outcomes.
5

Because the threshold of 3 was established for NPi, not QPi, comparisons using this threshold for QPi should be considered exploratory.