Non-invasive radiogenomic mapping of the SMARCAL1-driven ferroptotic niche is associated with longitudinal MRD-negative surveillance in early-stage NSCLC - Takeaways - MDSpire

Non-invasive radiogenomic mapping of the SMARCAL1-driven ferroptotic niche is associated with longitudinal MRD-negative surveillance in early-stage NSCLC

  • By

  • Zehao Huang

  • JunDao He

  • Yue Li

  • ZhanYu Xu

  • Huajian Peng

  • Xiang Gao

  • HuaFu Zhou

  • JianJi Guo

  • Nuo Yang

  • May 25, 2026

  • 0 min

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  • 1

    Post-operative molecular residual disease (MRD) detection using ctDNA is a sensitive biomarker for early recurrence risk in early-stage NSCLC.

  • 2

    A pre-operative CT-derived Rad-Score was developed from 1,432 radiomic features to assess the tumor microenvironment in NSCLC patients.

  • 3

    High Rad-Score patients exhibited longer metastasis-free survival and maintained MRD negativity, independent of clinical covariates.

  • 4

    The study identified a correlation between high Rad-Score tumors and increased TMB, CD8+ T cells, M1 macrophages, and ferroptotic activity.

  • 5

    SMARCAL1 knockout in cell lines demonstrated resistance to ferroptosis and reduced CXCR3+ CD8+ T cell transmigration, highlighting its role in immune response.

Original Source(s)

Non-invasive radiogenomic mapping of the SMARCAL1-driven ferroptotic niche is associated with longitudinal MRD-negative surveillance in early-stage NSCLC

  • by Zehao Huang, JunDao He, Yue Li, ZhanYu Xu, Huajian Peng, Xiang Gao, HuaFu Zhou, JianJi Guo, Nuo Yang

  • May 25, 2026

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