Association between HER2 expression, genomic characteristics, and tumor immune microenvironment dynamics in epithelial ovarian cancer - Takeaways - MDSpire

Linking HER2 Expression, Genomic Features, and Immune Microenvironment Changes in Epithelial Ovarian Cancer

  • By

  • Julia Salinaro

  • Payton De La Cruz

  • Shriya Perati

  • Julia McAdams

  • Samantha Buyungo

  • Janina Pearce

  • Areta Bojko

  • Angelica Salaverria

  • Kamaljeet Singh

  • Paul DiSilvestro

  • Cara Mathews

  • Nicole E. James

  • July 20, 2026

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  • 1

    The study analyzed 130 patients with HER2-expressing epithelial ovarian cancer (EOC) to understand genomic and immunogenic characteristics.

  • 2

    Non-significant differences were found in HRD, CCNE1 amplification, and ARID1A status between HER2 high and low tumors in the EOC cohort.

  • 3

    HER2 high tumors exhibited lower FOLR1 positivity and higher PD-L1 positivity compared to HER2 low tumors.

  • 4

    Intratumoral PD-L1 expression and CD4+ T cell levels were significantly higher in HER2 high tumors.

  • 5

    Treatment with trastuzumab deruxtecan (T-DXd) downregulated PD-L1 and VEGFA expression in EOC cell lines.

Original Source(s)

Association between HER2 expression, genomic characteristics, and tumor immune microenvironment dynamics in epithelial ovarian cancer

  • by Julia Salinaro, Payton De La Cruz, Shriya Perati, Julia McAdams, Samantha Buyungo, Janina Pearce, Areta Bojko, Angelica Salaverria, Kamaljeet Singh, Paul DiSilvestro, Cara Mathews, Nicole E. James

  • July 20, 2026

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