Do antihistamines help atopic dermatitis?

First-generation H1 antihistamines likely increase cognitive impairment, with cognitive effects differing among second-generation antihistamines.

1

Oral antihistamines may not significantly improve disease severity or itch in atopic dermatitis patients.
2

First-generation H1 antihistamines likely increase cognitive impairment and treatment discontinuation due to adverse events.
3

Second-generation H1 antihistamines showed minimal reductions in objective Scoring Atopic Dermatitis scores compared to placebo.
4

No clinically important difference was found for sleep disturbance or atopic dermatitis exacerbations with antihistamine use.
5

The systematic review included 47 trials with 6,230 patients and assessed treatment effects using Bayesian random-effects network meta-analyses.

1