Outcomes of Treatment and Factors Influencing Prognosis in Ugandan Children with Acute Myeloid Leukaemia - Takeaways - MDSpire

Outcomes of Treatment and Factors Influencing Prognosis in Ugandan Children with Acute Myeloid Leukaemia

  • By

  • Richard Nyeko

  • Mariana Kruger

  • Nixon Niyonzima

  • Barnabas Atwiine

  • Jennifer Zungu

  • Joyce Balagadde Kambugu

  • Stijn Verhulst

  • Jaques van Heerden

  • December 18, 2025

  • 0 min

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  • 1

    Paediatric acute myeloid leukaemia (AML) poses significant treatment challenges in low- and middle-income countries, leading to high morbidity and mortality.

  • 2

    Survival rates for children with AML in low-income countries remain below 40%, primarily due to late presentation and lack of standardized treatment protocols.

  • 3

    Prognosis for paediatric AML is influenced by genetic abnormalities, minimal residual disease negativity, and various clinical factors such as age and ethnicity.

  • 4

    In Uganda, a study revealed a 30-day induction mortality rate of 32% and a 12-month mortality rate of 70% among children treated for AML.

  • 5

    Limited access to advanced supportive care and treatment facilities exacerbates the poor outcomes for paediatric AML in Uganda and similar low-income settings.

Original Source(s)

Outcomes of Treatment and Factors Influencing Prognosis in Ugandan Children with Acute Myeloid Leukaemia

  • by Richard Nyeko, Mariana Kruger, Nixon Niyonzima, Barnabas Atwiine, Jennifer Zungu, Joyce Balagadde Kambugu, Stijn Verhulst, Jaques van Heerden

  • December 18, 2025

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