Optimal timing of cranioplasty post-decompressive craniectomy in traumatic brain injury: a systematic review, meta-analysis, and overview of ongoing trials - Takeaways - MDSpire

Optimal timing of cranioplasty post-decompressive craniectomy in traumatic brain injury: a systematic review, meta-analysis, and overview of ongoing trials

  • By

  • Ashviniy Thamilmaran

  • Shaan Patel

  • Shiva A. Nischal

  • Honey Panchal

  • Kush Kale

  • Pious D. Patel

  • Jack Jallo

  • James S. Harrop

  • January 8, 2026

  • 0 min

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  • 1

    Traumatic brain injury (TBI) is a leading cause of injury-related death and disability, affecting 50–60 million people globally.

  • 2

    Decompressive craniectomy (DC) is performed to alleviate refractory intracranial pressure but increases risks of severe disability.

  • 3

    Cranioplasty (CP) is necessary post-DC to restore skull protection, but optimal timing for CP remains debated among clinicians.

  • 4

    Early cranioplasty (EC) may offer functional advantages but could increase complication risks compared to late cranioplasty (LC).

  • 5

    This systematic review aims to clarify the effects of CP timing on outcomes and inform evidence-based clinical recommendations.

Original Source(s)

Optimal timing of cranioplasty post-decompressive craniectomy in traumatic brain injury: a systematic review, meta-analysis, and overview of ongoing trials

  • by Ashviniy Thamilmaran, Shaan Patel, Shiva A. Nischal, Honey Panchal, Kush Kale, Pious D. Patel, Jack Jallo, James S. Harrop

  • January 8, 2026

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