Inflammaging and osteoarthritis - therapeutic opportunities - Takeaways - MDSpire

Inflammaging and osteoarthritis - therapeutic opportunities

  • By

  • Megan Chan

  • Phoebe Low

  • Shi Chee Ong

  • Sze Mun Choy

  • Wen Xing Lee

  • Kah Yong Goh

  • Kanya Moolsuwan Ng

  • Kimberly Chua

  • Jia Ying Lee

  • Alvin Kunyao Guo

  • Jiang Jia

  • Eng King Tan

  • Hong-Wen Tang

  • Kenon Chua

  • June 23, 2026

  • 0 min

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  • 1

    Cellular senescence leads to the senescence-associated secretory phenotype (SASP), which drives chronic inflammation and cartilage degradation in osteoarthritis (OA).

  • 2

    Pro-inflammatory cytokines such as IL-1, TNF, and IL-6 play a central role in the inflammatory microenvironment, disrupting joint tissue homeostasis in OA.

  • 3

    Accumulation of senescent chondrocytes and macrophages activates signaling pathways like NF-κB and MAPK/p38, sustaining inflammation and extracellular matrix breakdown.

  • 4

    Pharmacological agents like anakinra, metformin, and rapamycin show potential in reducing inflammation and preserving cartilage in OA through modulation of SASP-related pathways.

  • 5

    Emerging gene-based approaches, including microRNA modulation and CRISPR/Cas9 editing, offer novel strategies to regulate SASP factors at the transcriptional level.

Original Source(s)

Inflammaging and osteoarthritis - therapeutic opportunities

  • by Megan Chan, Phoebe Low, Shi Chee Ong, Sze Mun Choy, Wen Xing Lee, Kah Yong Goh, Kanya Moolsuwan Ng, Kimberly Chua, Jia Ying Lee, Alvin Kunyao Guo, Jiang Jia, Eng King Tan, Hong-Wen Tang, Kenon Chua

  • June 23, 2026

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