Neutrophil α-defensin-1 is present in human stroke thrombi and induces NETosis in vitro - Takeaways - MDSpire

Neutrophil α-defensin-1 is present in human stroke thrombi and induces NETosis in vitro

  • By

  • Edward Theodore Littleton

  • Samuel George Thomas

  • Eleanor Woodhead

  • Julie Rayes

  • Alexander Brill

  • May 29, 2026

  • 0 min

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  • 1

    α-Defensin-1 is present in all analyzed ischemic stroke thrombi, primarily in regions enriched with neutrophils.

  • 2

    Neutrophil extracellular traps (NETs) are prominent in stroke thrombi, contributing to thrombus stability and resistance to fibrinolysis.

  • 3

    In vitro, α-defensin-1 significantly induces NETosis in human neutrophils at a concentration of 10 µg/mL.

  • 4

    The study suggests that α-defensin-1 may serve as an endogenous trigger for NET formation within stroke thrombi.

  • 5

    These findings highlight the potential role of α-defensin-1 in linking neutrophil degranulation to thrombus composition in ischemic stroke.

Original Source(s)

Neutrophil α-defensin-1 is present in human stroke thrombi and induces NETosis in vitro

  • by Edward Theodore Littleton, Samuel George Thomas, Eleanor Woodhead, Julie Rayes, Alexander Brill

  • May 29, 2026

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