Menstrual Fluid May Aid in Endometriosis Detection - Takeaways - MDSpire

Menstrual Fluid May Aid in Endometriosis Detection

Single-nucleus sequencing of menstrual fluid identified epithelial gene signatures and prioritized five candidate biomarkers that warrant validation in larger studies.

  • By

  • Andrea Surnit

  • July 13, 2026

  • 3 min

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  • 1

    Menstrual fluid from endometriosis patients shows distinct endometrial epithelial signatures detectable in RNA analysis.

  • 2

    A pilot study analyzed menstrual fluid from 5 endometriosis patients and 5 healthy controls using RNA sequencing.

  • 3

    The study identified 36 upregulated and 53 downregulated epithelial genes associated with endometriosis.

  • 4

    Five genes were differentially expressed in both single-nucleus and bulk RNA analyses, with KCNK5 as a potential biomarker.

  • 5

    The study's limitations include a small sample size and variability in menstrual fluid composition among donors.

Original Source(s)

Menstrual Fluid May Aid in Endometriosis Detection

  • by Andrea Surnit

  • July 13, 2026

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